The Neutrophil to Lymphocyte Ratio: An Emerging Diagnostic Biomarker for Parainflammation
International Blood Research & Reviews,
The present century health care system has made great innovations for the diagnosis and treatment of diseases. Despite this, the diagnosis of parainflammation is difficult due to absence of symptoms in individuals. The development of diseases could generally be mitigated by early detection and control of parainflammation since it appears to be a unifying factor for infectious and non-infectious diseases. The present review describes the value of the neutrophil to lymphocyte ratio as a biomarker for the detection of parainflammation in disease asymptomatic (apparently healthy) individuals.
- apparently healthy persons
- neutrophil to lymphocyte ratio
How to Cite
Needham EJ, Helmy A, Menon DK.The immunological response to traumatic brain injury. Journal of Neuroimmunology. 2019; 15:112-125.
Dinh KM, Kaspersen KA, Mikkelsen S, Pedersen OB, Petersen MS, Thorner LW, Hjalgrim H, Rostgaaard K, Ullum H, Erikstrup C. Low grade inflammation is negatively associated with physical health-related quality of life in healthy individuals: Results from the Dannish Blood Donor Study (DBDS). Public Library of Science One. 2019;14:e0216339.
Ogbuabor AO, Nwobodo HA, Chukwurah FE. Parainflammation: An immunohemato-logical risk factor for the emergence and re-emergence of diseases. Journal of Immunology Research and Reports. 2022;2(3):1-2.
Ronnback C, Hansson E. The importance and control of low grade inflammation due to damage of cellular barrier systems that may lead to systemic inflammation. Frontiers in Neurology. 2019;10:533.
Plytycz B, Seljelid R. From inflammation to sickness: Historical perspective. Archives of Immunology Therapy Experts. 2003;51: 105-109.
Nissen-Meyer LSH, Seghatchian J. Donor health assessment - when is blood donation safe? Transfusion and Apheresis Sciences. 2019;58:113-116.
Ngo TQ, Truong MH. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio, novel biomarkers and applications in urology: An update. Journal of Regenerative Biology and Medicine. 2022;4(3):1-11.
Tsai DH, Reidiker M, Berchet A, Paccaud F, Waeber G, Vollenweider P, Bochud M. Effect of short- and long- term exposures to particulate matter on inflammatory markers levels in the general population. Environmental Science Pollution Research International. 2019;26:19697-19704.
Pahwa R, Royal A, Bansal P, Jialal L. Chronic inflammation in: Stat Pearls [Internet] Treasure Island (FL); Stat Pearls Publishing; 2022.
Song M, Graubard BI, Rabkin CS, Engels EA. Neutrophil-to-lymphocyte ratio and mortality in the united states general population. Scientific Reports. 2021; 11(464):1-9.
Uduagbamen PK, Oyelese AT, Yusuf AAO, Thompson MU, Alalade BAA, Ehioghae O. Neutrophil lymphocyte ratio as an inflammatory marker in chronic kidney disease: Determinants and correlates. Open Journal of Nephrology. 2022;12:23-35.
He X, Qi S, Zhang X, Pan J. The relationship between the neutrophil-to-lymphocyte ratio and diabetic retinopathy in adults from the united states: Results from the National Health and Nutrition Examination Survey. BMC Ophthalmology. 2022;22(346):1-8.
Kara SP, Altunan B, Unal A. Investigation of the peripheral inflammation(Neutrophil-lymphocyte ratio) in two neurodegenerative diseases of the central nervous system. Neurological Sciences. 2022;43:1799-1807.
Lubis HH, Lubis HW, Kembaren T. Relationship between neutrophil lymphocyte ratio (NLR) and anxiety levels among covid-19 patients at Adam Malik General Hospital Medan. International Journal of Research and Reviews. 2021;8(12):378-383.
Rinaldi FX, Lembar S, Ridjab DA, Leonardo, Lauryn J, Erlina SGG. Correlation between neutrophil to lymphocyte ratio (NLR) and patients with heart failure: Hematology variables in patients with heart failure. Sriwijaya Journal of Medicine. 2021;5(1):10-17.
Demir M. Does inflammation play a role in the pathophysiology of tinnitus? Nigerian Journal of Clinical Practice. 2021;24:199-204.
Rathod BD, Amle D, Khot RS, Prathipati KK, Joshi PP. Neutrophil to lymphocyte ratio as a predictor of disease severity and mortality in coronavirus disease 2019: Prospective study from central India. Cureus. 2022;14(3):e23696.
Buonacera A, Stancanelli B, Colaci M, Malatino L. Neutrophil to lymphocyte ratio: an emerging marker of the relationships between the immune system and diseases. International Journal of Molecular Sciences. 2022;23(3636):1-10.
Ljungstrom L, Pernestg A, Jacobsson G, Anderson R, Usener B, Tilevik D. Diagnostic accuracy of procalcitonin, neutrophil-lymphocyte count ratio, C-reactive protein and lactate in patients with suspected bacterial sepsis. Public Library of Science. 2017;12(7):e0181704.
Suhartono, Wijaya I, Dalimoenthe NZ. The correlation of neutrophil to lymphocyte ratio (NLR) and monocytes to lymphocyte ratio (MLR) with disease severity in hospitalized patients with coronavirus disease 2019 (covid-19). Bali Medical Journal. 2021;10(2):653- 658.
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