International Blood Research & Reviews <p style="text-align: justify;"><strong>International Blood Research &amp; Reviews (ISSN:&nbsp;2321–7219)</strong> aims to publish high quality papers (<a href="/index.php/IBRR/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of ‘Blood related research’. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.</p> en-US (International Blood Research & Reviews) (International Blood Research & Reviews) Mon, 01 Jun 2020 09:02:28 +0000 OJS 60 Sickle Cell Disease - A Comprehensive Study and Usage of Technology for Diagnosis <p>Sickle cell is haematological disorder (haematology is a study of blood in health and diseases) which may lead to an organ damage, heart strokes and serious complications. It may also reduce human life span. Most of the sickle cells are observed in new born babies. At the start of sickle cells in human people though it’s a kind of feature in tribal people but it has spread over the world. Sickle cell Symptoms are observed in human beings as episodes of pains (crisis), Vision problems, swelling of hands and Feet. Sickle Cell Disease (SCD) can harm patient’s spleen (slightly pain at left Ribs). If one organ is affected in human body, then slowly it affects the entire body by spreading into Brain, Lungs, Heart, Liver, Kidneys, Joints, Eyes, Penis, Skin or Bone. This paper is aimed at presenting the complete details of the SCD with its properties, symptoms, signs, treatment for this disease. This is also a comprehensive study and characteristics of this disease with other similar diseases. The technological implications and usage in the field of SCD for better accuracy of identification of the disease is presented.</p> Sagar Yeruva, M. Sharada Varalakshmi, B. Pavan Gowtham, Y. Hari Chandana, P. E. S. N. Krishna Prasad ##submission.copyrightStatement## Fri, 19 Jun 2020 00:00:00 +0000 Platelet Volume Indices in Patients with Acute Coronary Syndrome <p><strong>Background &amp; Aims: </strong>Acute coronary syndrome is one of the leading causes of morbidity and mortality in the world and platelet hyperactivity with local platelet activation plays a crucial role in its genesis. As there is discrepancy regarding the significance of deranged platelet parameters, we aimed to study the role of platelet volume indices in the spectrum of coronary artery syndrome and to correlate them clinically.</p> <p><strong>Study Design: </strong>The study was conducted by collecting the data of patients with Myocardial infarction from the Cardiac care unit registry along with their clinical history and investigations. Stable coronary artery cases were collected from the Catheterization Lab and compared with Age and Sex matched controls. All CBCs of the above groups were processed by a 5-part counter and the data generated was transferred to a master chart for statistical analysis.</p> <p><strong>Place and Duration of study: </strong>The study was conducted in the Central Laboratory &amp; Department of Pathology at D.Y. Patil Hospital, Navi Mumbai, India in collaboration with the Cardiac Care Unit and Catheterisation Lab of the hospital for a period of two years.</p> <p><strong>Methods: </strong>A total of 122 cases were studied and grouped into 5 groups according to presentation and the platelet volume indices of these were compared with 38 matched controls and statistically analysed.</p> <p><strong>Results: </strong>Mean Platelet Volume and Platelet Distribution Width of patients with ST elevation Myocardial Infarction (STEMI) and Non ST elevation Myocardial Infarction(NSTEMI) were increased marginally in number when compared to Stable Coronary Artery Disease(SCAD) and Control group, however this was not statistically significant. Platelet Large Cell Ratio (PLCR) was significantly raised in STEMI cases only (P = 0.09), so it may prove to be a better marker for the disease (P = 0.09). Platelet counts in various groups when compared with controls gave inconsistent results i.e SCAD vs Control significantly decreased (<em>P</em> = 0.07) and STEMI vs Control significantly increased (<em>P</em> = 0.01).</p> <p><strong>Conclusion: </strong>The platelet volume indices in suspected acute coronary syndrome cases showed various changes, but present data failed to be diagnostically significant. However this data may later help to characterise further relationship between Acute coronary syndrome and platelet function in subsequent studies.</p> Ekta Paramjit, S. Sudhamani, Anita Sharan, Sonali Pitale, Prakash Roplekar ##submission.copyrightStatement## Mon, 01 Jun 2020 00:00:00 +0000 Transfusion Transmitable Infections and Reasons for Release of Total Blood to the Blood Bank of the Yaounde Centrall Hospital <p>Blood banks in sub-Saharan Africa regularly face shortages of blood products (PS). Several factors are responsible for this, including transfusion-transmissible infections (ITT) and deficiencies in the transfusion system. This study aims to determine the prevalence and the various reasons for rejection at the blood bank of the Central Hospital of Yaoundé. We first conducted a retrospective study at the blood bank of the Central Hospital of Yaoundé for 12 months between January 01, 2014 and December 31, 2014.Secondly, we carried out a prospective study in October 2015. Five milliliters (05 ml) of venous blood were taken from each participant in a tube without anticoagulant; patient samples were stored at -24°C. A rapid screening test and ELISA were used to test for HIV, HCV, HBs and syphilis on the samples taken. Approximately 15,028 bags of whole blood were drawn in 2014, of which 3,688 bags were rejected. This equates to a rejection rate of 24.54%. Discards for non-infectious reasons represented 3.51% and rejections for infectious reasons 21.03%. During the prospective study, among those selected, there were 95.74% men and 4.26% women. The average age of the participants was 30 years. Among the 705 people in this investigation, 185 blood bags were rejected. Infectious causes represented 22.55% (Hepatitis B and C, HIV and syphilis with a respective prevalence of 9.08%, 0.71% 6.95% and 5.82%) and non-infectious causes represented 3.68 % (clots, insufficient volume of PST, hemolysis and expiration with a respective prevalence of: 1.84%, 0.71 0.14% and 0.99%).The association between rejection of blood bags and qualitative variables was assessed. There emerged a significant association between the risk of rejection of a blood bag and the type of donor; condom use, number of partners, history of STIs. At the Yaoundé Central Hospital blood bank, the reasons for rejecting blood bags are divided into two categories: Mainly infectious and non-infectious. Also, certain risk variables such as not using a condom, multiple sexual partners and a history of STIs are risk factors that can encourage rejection of blood bags.</p> Chetcha C. Bernard ##submission.copyrightStatement## Fri, 19 Jun 2020 00:00:00 +0000